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Annie's avatar

The data on Cobenfy stinks. Given its proposed mechanism of action I find it astounding that dry mouth is supposed to be reported in under 5% of participants. Likewise, I would have expected nausea and headache to be reported at far higher rates.

I don't think such side effects are taken seriously enough. I had the misfortune of being diagnosed at age 37 with bipolar disorder. I was a senior lecturer in Psychology at the time, and was "treated" with quetiapine, and then quetiapine XL, as well as with sertraline, trazadone, and duloxetine at different points. Trying to lecture for 2hrs with a dry mouth like the Sahara was ridiculous, leading to me drinking 2 litres of juice, overheating, and needing to pee constantly.

Likewise, the sedation of quetiapine from having to take it in the morning (as well as evening) is not compatible with holding down a job. That might be the point. I was moved onto quetiapine XL because it triggered restless leg syndrome (of which the pramipexole triggered a psychotic episode and put me in the hospital after I planned to set myself on fire 😬), and the procyclidine for antithesia caused more cognitive impairment on top of the cognitive impairment caused by quetiapine XL. It was a hellish period compounded by a psychiatrist who would not listen, and would shout at me to never mention side effects ever again because quetiapine has no side effects, apparently.

These medications actively prevent you from being able to work, keep your job, and do anything remotely normal. I am off all psychiatric drugs now since 2019, discharged, have permanent severe RLS now treated via a neurologist, still have cognitive impairment and feel permanently apathetic, and unemployed.

Delphine Ryan's avatar

Thank you for exposing psychiatry. It is very hopeful to find like-minded people.

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